PEGylated β-Cell-Targeting Exosomes from Mesenchymal Stem Cells Improve β Cell Function and Quantity by Suppressing NRF2-Mediated Ferroptosis
MSC-EXO suppresses NRF2-mediated ferroptosis by delivering bioactive proteins to regulate the AKT/ERK signaling pathway, thereby improving the function and quantity of β cells. Additionally, Apt-EXO may serve as a novel drug carrier for islet-targeted therapy.
Authors
- Nan Zang (ORCID: https://orcid.org/0000-0001-5561-8068)
- Longqing Xia (ORCID: https://orcid.org/0009-0008-2338-2482)
- Jingwen Yang (ORCID: https://orcid.org/0000-0002-9195-308X)
- Xinguo Hou (ORCID: https://orcid.org/0000-0003-2045-1290)
- Liming Wang (ORCID: https://orcid.org/0009-0003-4666-8890)
- Huiqing Hu (ORCID: https://orcid.org/0009-0007-6916-159X)
- Jia Song (ORCID: https://orcid.org/0000-0002-5221-9915)
- Mengmeng Yang (ORCID: https://orcid.org/0000-0002-8988-269X)
- Xiaoyu Lv
- Li Chen (ORCID: https://orcid.org/0000-0001-7670-8062)
- Jun Chen (ORCID: https://orcid.org/0000-0001-7186-8964)
- Kewei Wang (ORCID: https://orcid.org/0000-0001-6504-5750)
- Ying Zou (ORCID: https://orcid.org/0009-0008-8960-8886)
- Yingyue Xiang
Institutions
- Shandong University (CN)
- University of Jinan (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/ijn.s459077
- Citations
- 18
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.21