Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of patients with colon cancer
Chemoresistance represents a major issue affecting cancer therapy efficacy. Because microRNAs (miRNAs) regulate gene expression on multiple levels, their role in chemoresistance development is reasonably certain. In our previous study, miR-122-5p and miR-142-5p were identified as diagnostic, prognostic, and predictive biomarkers for primary and metastatic rectal cancer. The aim of the present study was to investigate whether these miRNAs can also reflect the disease course of patients with colon cancer (CC). Further, we focused on a deeper understanding of their involvement in 5-fluorouracil (5-FU) chemoresistance development.
Authors
- Saba Selvi (ORCID: https://orcid.org/0000-0002-6965-1384)
- Vendula Novosadová (ORCID: https://orcid.org/0000-0003-0912-0562)
- Veronika Vymetálková (ORCID: https://orcid.org/0000-0001-6870-6788)
- Josef Horak (ORCID: https://orcid.org/0000-0003-2688-4273)
- Miroslav Levý (ORCID: https://orcid.org/0000-0003-3321-6644)
- Klara Vokacova
- Aneta Landecka
- Katerina Manakova
Institutions
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
- Thomayer University Hospital (CZ)
Publication Details
- Journal
- Mutagenesis
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1093/mutage/geae023
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Ministerstvo Zdravotnictví Ceské Republiky
- Agentura Pro Zdravotnický Výzkum České Republiky