Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model
Our study provides a comprehensive evaluation of UCB-Exos on the neuroprotective effects and suggests that inhibition of hyperphosphorylation of MAPK p38 and ERK 1/2 signaling pathways by regulating transcription levels of HspB1 and Ppef2 may be the key mechanism for UCB-Exos to improve PD-related pathological features.
Authors
- Shenglan Feng (ORCID: https://orcid.org/0009-0002-0923-7445)
- Qi Jiang (ORCID: https://orcid.org/0000-0002-2686-3934)
- Ming Sang (ORCID: https://orcid.org/0000-0003-2322-0674)
- Bingqing Qin (ORCID: https://orcid.org/0009-0001-2528-8456)
- Junjie Ye (ORCID: https://orcid.org/0009-0000-4492-0691)
- Lixia Xie (ORCID: https://orcid.org/0009-0001-8725-8367)
- Xiaodong Sun (ORCID: https://orcid.org/0000-0002-6447-0760)
- Jianjun Gui (ORCID: https://orcid.org/0009-0000-9689-3349)
- Ai Guo
- Jinju Dong
Institutions
- Hubei University of Medicine (CN)
- Wuhan University (CN)
- Taihe Hospital (CN)
- Wuhan Asia Heart Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s12951-024-02773-1
- Citations
- 15
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- Health Commission of Hubei Province
- Hubei University of Medicine
- Hubei University