A randomized, double-blind, placebo-controlled phase II study of olanzapine-based prophylactic antiemetic therapy for delayed and persistent nausea and vomiting in patients with HER2-positive or HER2-low breast cancer treated with trastuzumab deruxte
Olanzapine 5 mg for 6 days with 5-hydroxytryptamine type 3 receptor antagonist and dexamethasone appears effective for T-DXd-treated patients to prevent delayed and persistent nausea and vomiting.
Authors
- Takashi Yamanaka (ORCID: https://orcid.org/0000-0003-0117-5710)
- Junji Tsurutani (ORCID: https://orcid.org/0000-0002-6260-6943)
- Yasutaka Chiba (ORCID: https://orcid.org/0000-0002-7261-2351)
- Chiyo K. Imamura (ORCID: https://orcid.org/0000-0003-2907-847X)
- Mari Yamamoto (ORCID: https://orcid.org/0000-0003-3927-399X)
- Toshimi Takano (ORCID: https://orcid.org/0000-0002-8417-5291)
- Michio Tokiwa
- Michiko Tsuneizumi
- Hiroshi Ishiguro (ORCID: https://orcid.org/0000-0002-9859-5932)
- Yukinori Ozaki (ORCID: https://orcid.org/0000-0002-8064-648X)
- Koji Matsumoto (ORCID: https://orcid.org/0000-0003-1907-0247)
- Daisuke Takiguchi
- Hitomi Sakai (ORCID: https://orcid.org/0000-0001-8396-9121)
- Kazuki Nozawa (ORCID: https://orcid.org/0000-0002-0277-8196)
- Y. Miyoshi
- T. Iwasa
- Yaoko Takano
- Tutomu Ezumi
- Chiyoe Kitagawa
- K. Aogi
Institutions
- SHOWA Medical University (JP)
- Translational Research Institute (AU)
- Hyogo Medical University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- Nagoya University Hospital (JP)
- Kindai University Hospital (JP)
- Daiichi-Sankyo (Japan) (JP)
- Saitama International Medical Center (JP)
- Aichi Cancer Center (JP)
- Shizuoka General Hospital (JP)
- Shikoku Cancer Center (JP)
- Hokkaido University Hospital (JP)
- Nagoya Medical Center (JP)
- Kobe City Medical Center General Hospital (JP)
- Hyogo Prefectural Cancer Center (JP)
- Japanese Foundation For Cancer Research (JP)
- Saitama Medical University (JP)
- Kindai University (JP)
Publication Details
- Journal
- Annals of Oncology
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1016/j.annonc.2024.09.001
- Citations
- 16
- Primary Topic
- Nausea and vomiting management
- Type
- article
- Field-Weighted Citation Impact
- 9.16
Funders
- Daiichi Sankyo Company
- Daiichi Sankyo Europe