The extracellular vesicle of depressive patient-derived Escherichia fergusonii induces vagus nerve-mediated neuroinflammation in mice
esEVs may be translocated into the brain via the vagus nerve and bloodstream, subsequently inducing TNF-α expression and suppressing serotonin, its receptor, and BDNF expression through the activation of TLR4-mediated NF-κB signaling, thereby contributing to DA pathogenesis.
Authors
- Yoon-Jung Shin (ORCID: https://orcid.org/0000-0002-8308-905X)
- Hee-Seo Park (ORCID: https://orcid.org/0000-0001-7887-7900)
- Seung-Won Han
- Jung Kyung Hong (ORCID: https://orcid.org/0000-0002-1893-7868)
- In‐Young Yoon (ORCID: https://orcid.org/0000-0002-3995-8238)
- Jeon-Kyung Kim (ORCID: https://orcid.org/0000-0001-6746-6364)
- Xiaoyang Ma (ORCID: https://orcid.org/0000-0002-8198-6785)
- Dong‐Hyun Kim (ORCID: https://orcid.org/0000-0003-4783-7900)
Institutions
- University of Suwon (KR)
- Seoul National University Bundang Hospital (KR)
- Kyung Hee University (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s12974-024-03211-7
- Citations
- 21
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 5.20
Funders
- National Research Foundation of Korea