Target attainment of beta-lactam antibiotics and ciprofloxacin in critically ill patients and its association with 28-day mortality
A high rate of target attainment (100 % ƒT<sub>>1xECOFF</sub>) for beta-lactams and a lower rate for ciprofloxacin was observed. Achieving exposures of 100 % ƒT<sub>>4xECOFF</sub> was associated with 28-day mortality. The impact of antibiotic target attainment on clinical outcome needs to be a focus of future research.
Authors
- Birgit C. P. Koch (ORCID: https://orcid.org/0000-0002-1202-3643)
- Tim M. J. Ewoldt (ORCID: https://orcid.org/0000-0002-2918-2210)
- Nelianne J. Verkaik (ORCID: https://orcid.org/0000-0003-2351-2669)
- Alan Abdulla (ORCID: https://orcid.org/0000-0002-2158-6376)
- Wim J. R. Rietdijk (ORCID: https://orcid.org/0000-0002-2622-7321)
- Henrik Endeman (ORCID: https://orcid.org/0000-0002-2011-5169)
- Peter Van de Vliet (ORCID: https://orcid.org/0000-0002-1434-3659)
- Ilse M. Purmer (ORCID: https://orcid.org/0000-0002-8272-8040)
- Michael Osthoff (ORCID: https://orcid.org/0000-0001-5439-957X)
- Sarah Dräger (ORCID: https://orcid.org/0000-0001-9410-7404)
Institutions
- Erasmus MC (NL)
- University Hospital of Basel (CH)
- Medisch Centrum Haaglanden (NL)
Publication Details
- Journal
- Journal of Critical Care
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1016/j.jcrc.2024.154904
- Citations
- 4
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.79