The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis
Zbtb24 seems to regulate antibody responses against TD-Ags B cell extrinsically, but it specifically promotes the plasma cell differentiation of B1 cells via heme synthesis in mice. Our study also suggests that defected B1 functions contribute to recurrent infections in patients with ICF2.
Authors
- Fang‐Yuan Gong (ORCID: https://orcid.org/0000-0002-8532-4789)
- Hong-Min Wang (ORCID: https://orcid.org/0000-0002-5967-8110)
- Xiaoming Gao (ORCID: https://orcid.org/0000-0002-6058-8120)
- Xiaoqiu Dai
- Wei‐Long Zheng (ORCID: https://orcid.org/0000-0002-9474-6369)
- Wenliang Pan (ORCID: https://orcid.org/0009-0003-5965-2126)
- Xiao-Yuan Qin
- Sai Zhao (ORCID: https://orcid.org/0009-0009-2537-2285)
- Jun Wang (ORCID: https://orcid.org/0000-0002-4458-3741)
- He Gao
- Xuemei Zhu
- Tingting He (ORCID: https://orcid.org/0009-0009-1277-4971)
- Ying Zhao (ORCID: https://orcid.org/0000-0001-7135-8382)
- Can Zhu (ORCID: https://orcid.org/0009-0008-2623-6974)
- Jianfeng Dai (ORCID: https://orcid.org/0000-0002-9608-8064)
- Nan Zhang (ORCID: https://orcid.org/0009-0006-0411-738X)
Institutions
- Soochow University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s11658-024-00641-2
- Citations
- 1
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions