Single-cell mapping of peripheral blood mononuclear cells reveals key transcriptomic changes favoring coronary artery lesion in IVIG-resistant Kawasaki disease
Complex immunopathological changes occur during the development of CAL in IVIG-resistant KD. Stunted differentiation of CD8<sup>+</sup> effector T cells is noted in KD-CAL. Interactions between myeloid cells and T cells activates multiple inflammatory signaling pathways, with ligand-receptor pairs, including MIF-CD74/CXCR4 and MIF-CD74/CD44, potentially playing crucial roles.
Authors
- Qingtong Zhou (ORCID: https://orcid.org/0000-0001-8124-3079)
- Mei Feng (ORCID: https://orcid.org/0000-0002-0078-8809)
- Xing Fu (ORCID: https://orcid.org/0000-0001-5419-2691)
- Dehua Yang (ORCID: https://orcid.org/0000-0003-3028-3243)
- Yan Zhou (ORCID: https://orcid.org/0000-0002-8822-5276)
- Guoyou Qin (ORCID: https://orcid.org/0000-0002-1413-3117)
- Fang Liu (ORCID: https://orcid.org/0000-0002-1711-6347)
- Yuanzheng Zheng
- Feng Wang (ORCID: https://orcid.org/0000-0002-4591-3888)
- Cao Xie
- Ming‐Wei Wang (ORCID: https://orcid.org/0000-0001-6550-9017)
- Chu Chen (ORCID: https://orcid.org/0000-0003-2267-8050)
- Chenglong Liu (ORCID: https://orcid.org/0000-0001-7426-4808)
- Yonghao Gui (ORCID: https://orcid.org/0000-0002-5945-6622)
- Shuna Sun
- Di Zhu (ORCID: https://orcid.org/0009-0001-5159-3104)
Institutions
- Fudan University (CN)
- Shanghai Institute of Materia Medica (CN)
- National Center for Drug Screening (CN)
- Institute of Deep-Sea Science and Engineering (CN)
- Children's Hospital of Fudan University (CN)
- The University of Tokyo (JP)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37857
- Citations
- 10
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 5.73
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- Science and Technology Commission of Shanghai Municipality
- Hainan Provincial Department of Science and Technology
- National Major Science and Technology Projects of China