Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization
Our results indicate that inhibition of FetA reverses the progression of ALD in mice, implying that FetA can serve as a therapeutic target for the treatment of ALD.
Authors
- Tingcai Pan
- Keqing Jiang (ORCID: https://orcid.org/0000-0003-0708-5185)
- Songqing He (ORCID: https://orcid.org/0000-0002-8375-4048)
- Yanjun Chen (ORCID: https://orcid.org/0000-0001-9030-5673)
- Yan Li (ORCID: https://orcid.org/0000-0002-8259-2470)
- Dongxiao Li (ORCID: https://orcid.org/0000-0001-9195-7753)
- Jin Hu (ORCID: https://orcid.org/0000-0002-3234-1171)
- Fudi Zhong (ORCID: https://orcid.org/0000-0003-2606-1285)
- Long Kang (ORCID: https://orcid.org/0000-0002-4512-3296)
- Tiantian Nong
- Hao Xing (ORCID: https://orcid.org/0009-0002-3766-4727)
- Shibang Lu
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2024.09.011
- Citations
- 3
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China