Combination Therapy With Rituximab and Low-Dose Cyclophosphamide and Prednisone in Membranous Nephropathy

Low-dose triple therapy induced a rapid IR and CR in most patients. Patients with insufficient clinical response were characterized by high baseline PLA2Rab levels and longer PLA2Rab T<sub>1/2</sub>. Assessment of PLA2Rab levels within 2 to 4 weeks after start of therapy may enable to identify patients who need more intensive therapy.

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Publication Details

Journal
Kidney International Reports
Published
2024-09-13
DOI
https://doi.org/10.1016/j.ekir.2024.08.033
Citations
5
Primary Topic
Renal Diseases and Glomerulopathies
Type
article
Field-Weighted Citation Impact
1.70
Controls
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article

Combination Therapy With Rituximab and Low-Dose Cyclophosphamide and Prednisone in Membranous Nephropathy

Jack F.M. Wetzels, Coralien H. Vink, Anne-Els van de Logt
5 citations
Kidney International Reports
Renal Diseases and Glomerulopathies
1.70
article

Combination Therapy With Rituximab and Low-Dose Cyclophosphamide and Prednisone in Membranous Nephropathy

Jack F.M. Wetzels, Coralien H. Vink, Anne-Els van de Logt
article en
5 citations

Abstract

Low-dose triple therapy induced a rapid IR and CR in most patients. Patients with insufficient clinical response were characterized by high baseline PLA2Rab levels and longer PLA2Rab T<sub>1/2</sub>. Assessment of PLA2Rab levels within 2 to 4 weeks after start of therapy may enable to identify patients who need more intensive therapy.

Kidney International ReportsVol. 9(12)
Radboud University Nijmegen (NL), Radboud University Medical Center (NL), Radboud Institute for Molecular Life Sciences (NL)
Zero hunger
Openalex Percentile: Top 14%
Renal Diseases and Glomerulopathies
1.70
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