Impaired arterial dilation and increased NOX2 generated oxidative stress in subjects with ataxia-telangiectasia mutated (ATM) kinase
This study demonstrates that individuals with ATM mutations experience endothelial dysfunction, increased oxidative stress, and elevated thrombus formation. These factors collectively contribute to the heightened susceptibility of these individuals to develop atherosclerosis.
Authors
- Bianca Laura Cinicola (ORCID: https://orcid.org/0000-0003-1268-5038)
- Marzia Duse (ORCID: https://orcid.org/0000-0001-9958-2570)
- Pasquale Pignatelli (ORCID: https://orcid.org/0000-0002-2265-7455)
- Simona Bartimoccia
- Maurizio Forte (ORCID: https://orcid.org/0000-0003-0739-0534)
- Annarosa Soresina
- Alberto Spalice (ORCID: https://orcid.org/0000-0002-8455-796X)
- Vincenzo Leuzzi (ORCID: https://orcid.org/0000-0002-2314-6139)
- Martina Capponi
- Caterina Caputi (ORCID: https://orcid.org/0000-0001-5972-1185)
- Anna Maria Zicari (ORCID: https://orcid.org/0000-0002-2476-1790)
- Raffaele Badolato (ORCID: https://orcid.org/0000-0001-7375-5410)
- Roberto Carnevale (ORCID: https://orcid.org/0000-0002-6216-9595)
- Vittorio Picchio (ORCID: https://orcid.org/0000-0003-1591-5118)
- Francesco Violi (ORCID: https://orcid.org/0000-0002-6610-7068)
- Lorenzo Loffredo (ORCID: https://orcid.org/0000-0002-6542-6235)
- Roberto Poscia (ORCID: https://orcid.org/0000-0003-3068-635X)
- Francesca Salvatori (ORCID: https://orcid.org/0000-0001-8950-9978)
Institutions
- Policlinico Umberto I (IT)
- Istituto Neurologico Mediterraneo (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Redox Biology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.redox.2024.103347
- Citations
- 3
- Primary Topic
- Coenzyme Q10 studies and effects
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Ministero della Salute
- Sapienza Università di Roma