Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood
Our mathematical model predicted how variations in clotting protein levels, within the normal range, could contribute to the variability of bleeding phenotypes observed with clotting factor deficiencies. Our study generated experimentally testable hypotheses that could aid in developing new therapies toward normal hemostasis.
Authors
- Karin Leiderman (ORCID: https://orcid.org/0000-0002-4188-1305)
- Suzanne Sindi (ORCID: https://orcid.org/0000-0003-2742-4332)
- Aaron L. Fogelson (ORCID: https://orcid.org/0000-0002-8885-9420)
- Dougald M. Monroe (ORCID: https://orcid.org/0000-0002-0493-2943)
- Keith B. Neeves (ORCID: https://orcid.org/0000-0001-7546-4588)
- Michael T. Stobb (ORCID: https://orcid.org/0000-0002-6615-5596)
Institutions
- University of North Carolina at Chapel Hill (US)
- Coe College (US)
- University of California, Merced (US)
- University of Utah (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.rpth.2024.102570
- Citations
- 2
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Science Foundation
- National Institutes of Health