Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis
This study elucidated the reno-protective effects for the first time, demonstrating that it exerts its beneficial effects through the gut microbiota, which mediate the LPS/TLR4/NF-κB/TNF-α inflammatory pathway. It may help to develop therapeutic approaches using toralactone and targeted restoration of the gut microbiota.
Authors
- Yunxi Chen (ORCID: https://orcid.org/0009-0006-0105-1741)
- Yan Pan (ORCID: https://orcid.org/0000-0003-4307-3616)
- Rongshan Li (ORCID: https://orcid.org/0000-0002-8082-4389)
- Ruixue Tian (ORCID: https://orcid.org/0000-0003-1193-9913)
- B. Wang (ORCID: https://orcid.org/0009-0003-9284-9852)
- Yan Tian (ORCID: https://orcid.org/0000-0002-4211-8117)
- Juan He
- Yafan Guo
Institutions
- Shanxi Medical University (CN)
- Jinzhong University (CN)
- Shanghai East Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.intimp.2024.113115
- Citations
- 4
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.70