Copper‐Catalyzed Trifunctionalization of Heteroaryl‐Substituted 1‐Hexenes <i>via</i> Remote Heteroaryl Migration
A copper-catalyzed trifunctionalization (trifluoromethylation, heteroarylation, and cyanation) of heteroaryl-substituted 1-hexenes via remote heteroaryl migration is reported. A variety of CF<sub>3</sub> and heteroaryl-containing nitriles were readily constructed under mild conditions. The reaction features high chemo- and regioselectivities and represents a convenient method for the synthesis of multifunctionalized molecules in organic synthesis.
Authors
- Kang Guo (ORCID: https://orcid.org/0009-0005-7316-502X)
- Qiong Wu
- Yongchao Lu (ORCID: https://orcid.org/0000-0002-6924-181X)
- Yanwen Sun (ORCID: https://orcid.org/0000-0001-7085-0797)
- Yining Sun
- Jiayi Shang
Institutions
- Hebei Normal University (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1002/asia.202400988
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.25