Recruitment of USP10 by GCS1 to deubiquitinate GRP78 promotes the progression of colorectal cancer via alleviating endoplasmic reticulum stress
In summary, GCS1 stimulates CRC growth and migration and reduces ER stress-mediated apoptosis via USP10-mediated deubiquitination of GRP78. Our findings identify a possible therapeutic target for CRC.
Authors
- Hengyang Shen
- Lei Xu (ORCID: https://orcid.org/0000-0003-1297-1210)
- Changzhi Huang
- Zan Fu (ORCID: https://orcid.org/0000-0002-3397-0770)
- Ying Tong
- Chen Yang (ORCID: https://orcid.org/0000-0002-1237-2632)
- Yunfei Lu (ORCID: https://orcid.org/0000-0002-9292-2517)
- Zhenling Wang (ORCID: https://orcid.org/0000-0002-6834-8607)
- Yu Shao
- Hongqiang Zhang (ORCID: https://orcid.org/0009-0006-5787-6689)
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1186/s13046-024-03176-8
- Citations
- 15
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 4.89
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province