STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A
These findings suggest that the STUB1-mediated ubiquitination of UHRF1 plays a pivotal role in tumor progression by epigenetically silencing PLA2G2A, underscoring the potential of STUB1 as both a prognostic biomarker and therapeutic target for CCA.
Authors
- Wenhua Huang (ORCID: https://orcid.org/0000-0003-2382-9180)
- Fei Xiong (ORCID: https://orcid.org/0000-0001-8723-2063)
- Yongjun Chen
- Guanhua Wu (ORCID: https://orcid.org/0000-0001-6285-9337)
- Bing Wang (ORCID: https://orcid.org/0000-0001-9646-0404)
- Junsheng Chen (ORCID: https://orcid.org/0000-0002-2934-8030)
- Wenzheng Liu (ORCID: https://orcid.org/0000-0003-0710-5748)
- Yongqiang Qi (ORCID: https://orcid.org/0000-0003-3399-5967)
- Da Wang (ORCID: https://orcid.org/0000-0003-1189-4663)
- Yiyang Kuai
- Qi Wang (ORCID: https://orcid.org/0009-0004-6707-6613)
Institutions
- Capital Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Beijing Friendship Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1186/s13046-024-03186-6
- Citations
- 8
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China