Impacts of aqueous extracts of Annona senegalensis and Hallea ledermannii on hematological parameters in Wistar rats made diabetic by alloxan induction.

Background: The costly treatment of diabetes mellitus is leading low-income populations to turn to phytotherapy, which requires preclinical testing to prevent dangerous side effects. Objective: To evaluate the impact of aqueous extracts of Annona senegalensis (EAAs) and Hallea ledermannii (EAHl) on the haematological parameters of diabetic Wistar rats. Material and methods: Diabetes was induced in normal rats by injection of alloxane. Diabetic rats were treated with the test substances for four (4) and thirteen (13) weeks. Haematological parameters were assayed after these treatments. Results: Significantly, after four (4) weeks of treatment, platelet values increased by (49.54%) in animals treated with EAAs100. White blood cell count increased by 41.12% and 60.66% in rats treated with EAHl200. After 13 weeks, in rats treated with EAHl400, an 84.32% increase (p<0.05) in platelets was observed. Neutrophil counts were statistically reduced by 34.92%, 53.97%, 49.21% and 53.97% respectively in diabetic rats treated with Gli10, EAAs100, EAAs200 and EAHl400, all compared with untreated diabetic rats. Conclusion: This study showed that EAAs and EAHl have the capacity to fight infections in the body by helping to regulate haematological parameters.