Radiation immunodynamics in patients with glioblastoma receiving chemoradiation
These data suggest that, as in chronic inflammatory disease, systemic immunity is impaired following delivery of adjuvant chemoradiotherapy. Finally, baseline investigation of myeloid cells within tumor tissue did not differ between survival groups, indicating immune surveillance of peripheral blood during adjuvant therapy may be a critical missing link to educate our understanding of the immune effects of standard of care therapy for glioblastoma.
Authors
- David Kamson (ORCID: https://orcid.org/0000-0002-0473-658X)
- Kristin J. Redmond (ORCID: https://orcid.org/0000-0003-3442-4613)
- Stuart A. Grossman (ORCID: https://orcid.org/0000-0002-3726-7679)
- Michael Lim (ORCID: https://orcid.org/0000-0003-0523-3076)
- Charles G. Eberhart (ORCID: https://orcid.org/0000-0002-2910-9427)
- Drew M. Pardoll
- Lindsey Sloan (ORCID: https://orcid.org/0000-0002-1904-8376)
- Chen Hu (ORCID: https://orcid.org/0000-0003-4672-1981)
- Harry Quon (ORCID: https://orcid.org/0000-0001-7605-4329)
- Lawrence Richard Kleinberg (ORCID: https://orcid.org/0000-0003-2473-2305)
- Rupashree Sen (ORCID: https://orcid.org/0000-0003-2121-6161)
- Lisa Katulis
- Sudipto Ganguly (ORCID: https://orcid.org/0000-0002-2662-8897)
- Chunnan Liu (ORCID: https://orcid.org/0000-0002-6396-1672)
- Lee Blosser
- Matthias Holdhoff (ORCID: https://orcid.org/0000-0002-3285-3484)
- Michèle Doucet
Institutions
- Bloomberg (United States) (US)
- University of Minnesota (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Minnesota Medical Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.3389/fimmu.2024.1438044
- Citations
- 9
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.94