Wee1 inhibitor PD0166285 sensitized TP53 mutant lung squamous cell carcinoma to cisplatin via STAT1
In summary, our study suggests that PD0166285, an inhibitor of Wee1, sensitizes LUSC cells to cisplatin and modulates DNA damage and apoptosis pathways through Rad51 and Stat1, respectively. These findings highlight the combination of PD0166285 and cisplatin as a promising therapeutic approach for treating LUSC.
Authors
- Daoming Zhang (ORCID: https://orcid.org/0000-0001-6455-6890)
- Yangling Li
- Binxin Chen (ORCID: https://orcid.org/0009-0008-0723-8966)
- Ping Li (ORCID: https://orcid.org/0000-0003-1055-9505)
- Qingyi Zhang (ORCID: https://orcid.org/0000-0002-6796-6999)
- Deng Jun (ORCID: https://orcid.org/0000-0001-6327-3549)
- Nengming Lin (ORCID: https://orcid.org/0000-0001-8392-3588)
- Qi Li (ORCID: https://orcid.org/0000-0002-0060-3376)
- Yiming Jiang
- Bo Zhang (ORCID: https://orcid.org/0000-0002-7167-4083)
- Huanqi Zhang
- Wenjie Yang (ORCID: https://orcid.org/0000-0002-3959-5043)
Institutions
- Zhejiang Chinese Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Zhejiang Pharmaceutical College (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Hangzhou Cancer Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1186/s12935-024-03489-w
- Citations
- 5
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Natural Science Foundation of Zhejiang Province