Effects of thyroid hormones modify the association between pre-pregnancy obesity and GDM: evidence from a mediation analysis
In conclusion, the low FT4, high FT3-to-FT4 ratio, and low TFQI in the first trimester significantly increase the risk of GDM and should be given more attention. Furthermore, increased pre-pregnancy BMI might partially increase the risk of GDM by influencing the body's thyroid function.
Authors
- Yan Zhuang (ORCID: https://orcid.org/0000-0002-1393-7092)
- Zhicheng Peng
- Haoyue Cheng (ORCID: https://orcid.org/0000-0002-3538-0678)
- Shuting Si
- Yunxian Yu (ORCID: https://orcid.org/0000-0002-3394-9832)
- Xialidan Alifu
- Yiwen Qiu (ORCID: https://orcid.org/0000-0003-0022-4824)
- Ze-xin Chase Chen (ORCID: https://orcid.org/0000-0002-9628-4567)
- Diliyaer Ainiwan
- Ye Huang (ORCID: https://orcid.org/0000-0001-6322-2346)
- Libi Zhang
- Haibo Zhou
- Peihan Chi
- Hui Liu (ORCID: https://orcid.org/0009-0003-3273-6979)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.3389/fendo.2024.1428023
- Citations
- 7
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Zhejiang University