Mechanism of emodin in treating hepatitis B virus-associated hepatocellular carcinoma: network pharmacology and cell experiments
This study, based on network pharmacology and molecular docking validation, suggests that emodin may exert therapeutic effects on HBV-related HCC by downregulating the expression of XRCC1, MAPK3, PCNA, HSP90AA1, and SOD2, and upregulating the expression of PTGS2 and GSTP1.
Authors
- Shuangxing Li
- Tianqi Ren
- Bo Li (ORCID: https://orcid.org/0000-0002-4456-7303)
- Yupeng Wang (ORCID: https://orcid.org/0000-0003-4170-3952)
- Yikun Zhang (ORCID: https://orcid.org/0000-0002-4048-4869)
- Xingchao Geng (ORCID: https://orcid.org/0009-0004-1605-2937)
Institutions
- China Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Medical Products Administration (CN)
- National Institutes for Food and Drug Control (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.3389/fcimb.2024.1458913
- Citations
- 5
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 3.00