2-Arylbenzofurans from the stems and leaves of <i>Artocarpus tonkinensis</i> and their potential antiproliferative activities

Phytochemical study on the stems and leaves of <i>Artocarpus tonkinensis</i> led to the isolation of a new 2-arylbenzofuran, artocartone (<b>1</b>), as well as seven known 2-arylbenzofurans (<b>2-8</b>). The chemical structure of <b>1</b> was established by means of comprehensive spectroscopic analyses and the known compounds were determined by comparing their MS and NMR data with those reported data in literature. The antiproliferative activities of all isolates <b>1-8</b> against five human cancer cell lines: HL-60, SMMC-7721, A-375, MCF-7 and SW480 <i>in vitro</i> were evaluated. As a result, compounds <b>1- 8</b> displayed notable antiproliferative activities against various human cancer cell lines with IC₅₀ values in the range of 0.28 ± 0.05-26.89 ± 0.18 μM.