B7‐H3 promotes nasopharyngeal carcinoma progression by regulating CD8+ T cell exhaustion
Our findings suggest that B7-H3 may accelerate tumor growth, tumor cell invasion, and EMT, and interact with 4-1BB to produce CD8+ T cell exhaustion that inhibits tumor immunity. B7-H3 might serve as a novel target for treating NPC.
Authors
- Wenjing Liao (ORCID: https://orcid.org/0000-0002-7766-6703)
- Zhaoen Ma
- Bailin Pan (ORCID: https://orcid.org/0000-0002-2563-8997)
- Saixuan Yang
- Xiaowen Zhang (ORCID: https://orcid.org/0000-0001-5255-8610)
- Hao Li (ORCID: https://orcid.org/0000-0003-0513-0771)
- Chen Gui (ORCID: https://orcid.org/0000-0003-0518-4956)
- Yali Xu (ORCID: https://orcid.org/0009-0007-7772-3548)
- Wuping Lai
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Jinan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/iid3.70005
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Guangzhou Medical University