Visual assessments of 11C-Pittsburgh compound-B PET vs. 18F-flutemetamol PET across the age spectrum
Age, GM/WM binding, amyloid-β load, and disease severity may affect visual assessments of PET ligands. Increase in WM binding with age causes a loss of contrast between GM and WM on 11 C-PiB-PET, particularly in CU younger adults, leading to false positivity. In CU older adults, increased WM signal may bleed more into cortical regions, hiding subtle cortical uptake, especially with 18 F-flutemetamol, whereas 11 C-PiB can detect true regional positivity. Understanding these differences will improve patient care and treatment evaluation in clinic and clinical trials.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Derek Richard Johnson (ORCID: https://orcid.org/0000-0002-4217-5517)
- Orhun H. Kantarci (ORCID: https://orcid.org/0000-0001-7038-8133)
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Bradley J. Kemp (ORCID: https://orcid.org/0000-0002-2360-2368)
- Burcu Zeydan (ORCID: https://orcid.org/0000-0002-2270-9868)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Timothy G. Lesnick (ORCID: https://orcid.org/0000-0002-4126-5924)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- Hoon‐Ki Min (ORCID: https://orcid.org/0000-0002-1084-2469)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
Publication Details
- Journal
- Nuclear Medicine Communications
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1097/mnm.0000000000001902
- Citations
- 3
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Institutes of Health