Transcriptional profile changes caused by noise-induced tinnitus in the cochlear nucleus and inferior colliculus of the rat
Our findings reveal gene expression alterations in neuronal excitability within the DCN and IC when comparing the tinnitus group to the non-tinnitus group at the transcriptome level. Additionally, the enriched signaling pathways related to changes in synaptic plasticity in the differentially expressed genes within the DCN suggest that the excitability changes may propagate to IC.
Authors
- Yuke Jiang
- Peng Liu (ORCID: https://orcid.org/0000-0002-2797-6949)
- Xinmiao Xue (ORCID: https://orcid.org/0000-0002-0005-4207)
- Zhiwei Ding (ORCID: https://orcid.org/0000-0003-3872-6512)
- Shiming Yang
- Li Wang (ORCID: https://orcid.org/0000-0002-6813-8060)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-6729-1426)
- Weidong Shen (ORCID: https://orcid.org/0000-0003-0021-3885)
- Fangyuan Wang (ORCID: https://orcid.org/0000-0002-9880-3930)
Institutions
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- PLA Academy of Military Science (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1080/07853890.2024.2402949
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.36