Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study
The peptide-based classifier demonstrated significant predictive value for mortality in post-acute COVID-19 patients, highlighting the utility of urinary peptides in prognosticating post-acute COVID-19 mortality, offering insights for targeted interventions. By utilizing these defined biomarkers in the clinic, risk stratification, monitoring, and personalized interventions can be significantly improved. Our data also suggest that mortality should be considered as one possible symptom or a consequence of post-acute sequelae of SARS-CoV-2 infection, a fact that is currently overlooked.
Authors
- Manfred Hecking (ORCID: https://orcid.org/0000-0002-8047-2395)
- Justyna Siwy (ORCID: https://orcid.org/0000-0003-1407-2534)
- Ralph Wendt (ORCID: https://orcid.org/0000-0003-1600-6581)
- Mirosław Banasik (ORCID: https://orcid.org/0000-0002-0588-1551)
- Łukasz Fuławka (ORCID: https://orcid.org/0000-0003-4858-2022)
- Harald Mischak (ORCID: https://orcid.org/0000-0003-0323-0306)
- Björn Peters (ORCID: https://orcid.org/0000-0003-1199-8948)
- Felix Keller (ORCID: https://orcid.org/0000-0002-8240-7255)
- Magdalena Dzitkowska-Zabielska (ORCID: https://orcid.org/0000-0002-7375-9814)
- Joachim Beige (ORCID: https://orcid.org/0000-0002-1907-825X)
- Marek Rajzer (ORCID: https://orcid.org/0000-0001-7074-7263)
- Alexandre Mebazaa (ORCID: https://orcid.org/0000-0001-8715-7753)
- Emmanuel Dudoignon (ORCID: https://orcid.org/0000-0003-0429-4889)
- Dilara Gülmez
- Goce Spasovski
- Mercedes Salgueira Lazo
Institutions
- Jagiellonian University (PL)
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Klinikum St. Georg (DE)
- Wroclaw Medical University (PL)
- Hospital Universitario Virgen Macarena (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Lariboisière (FR)
- Mosaiques Diagnostics and Therapeutics (Germany) (DE)
- KfH Kuratorium für Dialyse und Nierentransplantation (DE)
- Gdansk University of Physical Education and Sport (PL)
- Skaraborg Hospital (SE)
- Molecular Pathology Centre Cellgen
- Martin Luther University Halle-Wittenberg (DE)
- Gdańsk Medical University (PL)
- Medical University of Vienna (AT)
- Ss. Cyril and Methodius University in Skopje (MK)
- Universidad de Sevilla (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-09-13
- DOI
- https://doi.org/10.3390/biomedicines12092090
- Citations
- 5
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Västra Götalandsregionen
- Universidad de Sevilla
- Uniwersytet Jagielloński Collegium Medicum
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- VINNOVA
- Bundesministerium für Bildung und Forschung
- Austrian Science Fund
- Universität Wien
- Bundesministerium für Gesundheit
- Göteborgs Universitet
- Medizinische Universität Wien
- Assistance publique-Hôpitaux de Paris
- Śląski Uniwersytet Medyczny w Katowicach
- Uniwersytet Śląski w Katowicach
- Sorbonne Université
- Sahlgrenska Akademin