<i>SOD1</i> gene screening in ALS – frequency of mutations, patients’ attitudes to genetic information and transition to tofersen treatment in a multi-center program
The finding of <i>SOD1</i> variants in patients with a negative family history underscores the need for a broad genetic screening in ALS. In <i>SOD1</i>-ALS, the treatment option with tofersen was mostly utilized. The wide range in the transition time to tofersen calls for a <i>SOD1</i>-ALS management program.
Authors
- René Günther (ORCID: https://orcid.org/0000-0003-0329-5644)
- Maximilian Vidovic (ORCID: https://orcid.org/0000-0003-1453-1681)
- Patrick Weydt (ORCID: https://orcid.org/0000-0003-2344-5662)
- Petra Baum (ORCID: https://orcid.org/0000-0002-6926-4907)
- Sarah Bernsen (ORCID: https://orcid.org/0000-0001-7485-2626)
- Jenny Nordén
- Robert Steinbach (ORCID: https://orcid.org/0000-0003-3936-6010)
- Bertram Walter (ORCID: https://orcid.org/0000-0001-9086-5179)
- Christoph Münch (ORCID: https://orcid.org/0000-0001-9603-0623)
- David C. Kasper (ORCID: https://orcid.org/0000-0003-0534-6388)
- Peggy Schumann
- Thomas Meyer (ORCID: https://orcid.org/0000-0002-2736-7350)
- Jochen Hans Weishaupt (ORCID: https://orcid.org/0000-0002-3399-9784)
- Dagmar Kettemann (ORCID: https://orcid.org/0000-0001-5084-8526)
- André Maier (ORCID: https://orcid.org/0000-0003-2473-4116)
- Torsten Grehl (ORCID: https://orcid.org/0000-0002-0631-6976)
- Peter Körtvélyessy (ORCID: https://orcid.org/0000-0001-9990-2458)
- Moritz Metelmann (ORCID: https://orcid.org/0000-0002-8670-6148)
- Yasemin Koc
- Susanne Spittel (ORCID: https://orcid.org/0000-0001-9471-7798)
- Ute Weyen
- Julian Großkreutz (ORCID: https://orcid.org/0000-0001-9525-1424)
- Berthold Streubel
- Philipp Schmitt (ORCID: https://orcid.org/0009-0008-1643-0079)
- Susanne Petri
- Annekathrin Rödiger
- Joachim Wolf
Institutions
- University of Bonn (DE)
- University of Mannheim (DE)
- Heidelberg University (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Heidelberg (DE)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- University Hospital Leipzig (DE)
- Jena University Hospital (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- DIAKO (DE)
- Alfried Krupp Hospital (DE)
- University Hospital Carl Gustav Carus (DE)
- Freie Universität Berlin (DE)
- Medical University of Vienna (AT)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1080/21678421.2024.2401131
- Citations
- 6
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.21
Funders
- Biogen