Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy
In this study, a high-resolution single-cell transcriptomic atlas of the hippocampus in mice with TLE was established, revealing potential intrinsic mechanisms driving TLE-associated inflammatory activation and altered cell interactions. These findings provide valuable insights for further exploration of HS development and epileptogenesis.
Authors
- Jinkun Xu
- Penghu Wei (ORCID: https://orcid.org/0000-0002-4529-7691)
- Changkai Hou (ORCID: https://orcid.org/0000-0002-2043-088X)
- Guoguang Zhao (ORCID: https://orcid.org/0000-0002-7569-5252)
- Quanlei Liu
- Yongzhi Shan (ORCID: https://orcid.org/0000-0001-5510-1026)
- Hongyi Yang
- Yang Dai
- Yongchang Lu
- Yihe Wang (ORCID: https://orcid.org/0009-0000-5220-5452)
- Yunming Wang (ORCID: https://orcid.org/0000-0002-8557-0349)
- Ting Tang (ORCID: https://orcid.org/0009-0005-9078-2417)
- Chunhao Shen
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1186/s40364-024-00636-3
- Citations
- 27
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 6.31