DPDCD: The Intelligent Prediction Strategy for the Course Development of Diabetic Kidney Disease

Diabetic nephropathy (DKD) is a severe diabetes complication and a leading cause of mortality. While urine microalbuminuria and eGFR are common markers, some advanced cases may exhibit normal values. The progression from microalbuminuria to overt proteinuria in DKD is gradual and requires comprehensive physiological tests for diagnosis. This study employs deep reinforcement learning to predict DKD progression based on patients’ physiological data, aiming to assist clinical diagnosis and treatment. A multivariate logistic regression algorithm is used to describe the DKD prediction probability. An optimized DKD progression prediction algorithm (DPDCD) based on deep reinforcement learning determines the best model coefficients, enabling accurate prediction of DKD progression using routine clinical data. Experimental results demonstrate that DPDCD outperforms other algorithms in predicting DKD progression, providing valuable support for clinicians.