Silencing GDI2 inhibits proliferation, migration and invasion of colorectal cancer through activation of p53 signaling pathway
Silencing GDI2 activates the p53 signaling pathway by regulating RAB5A expression levels, which in turn induces cell cycle arrest and ultimately affects the proliferative activity, migration, and invasive ability of CRC cells.
Authors
- Feipeng Xu
- Zhenhao Quan
- Wen‐Ting Ou (ORCID: https://orcid.org/0000-0003-3090-8522)
- Jiawei Zhai
- Lijun Sun
- Caijin Zhou (ORCID: https://orcid.org/0000-0003-0951-9127)
- Rongjian Tan
- Xian-Jin Huang
Institutions
- Guangdong Medical College (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37770
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Guangdong Medical College