Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain’s drainage in healthy male mice
Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA.
Authors
- Alexander Shirokov (ORCID: https://orcid.org/0000-0003-4321-735X)
- Ivan V. Fedosov (ORCID: https://orcid.org/0000-0002-3619-245X)
- Oxana Semyachkina‐Glushkovskaya (ORCID: https://orcid.org/0000-0001-6753-7513)
- Sergey Popov (ORCID: https://orcid.org/0000-0002-4075-9092)
- Andrey Terskov
- Alexander Dubrovsky (ORCID: https://orcid.org/0000-0002-5897-9229)
- Matvey Tuzhilkin
- Alexander Dmitrenko
- Dmitry Myagkov (ORCID: https://orcid.org/0009-0002-7781-6721)
- Inna Blokhina (ORCID: https://orcid.org/0000-0003-1517-0857)
- Maria Manzhaeva
- Valeria Krupnova
- Daria Zlatogorskaya
- Egor Ilyukov
- Dmitry Tuktarov
- Arina Evsiukova
- Maria Tzoy
- Viktoria Adushkina
Institutions
- Saratov State University (RU)
- Institute of Biochemistry and Physiology of Plants and Microorganisms (RU)
Publication Details
- Journal
- Biomedical Optics Express
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1364/boe.527892
- Citations
- 3
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Russian Science Foundation