A CASE OF LATE-ONSET ADOPTIVE AUTOIMMUNITY IN AN ALLOGENEIC STEM CELL TRANSPLANT RECIPIENT

A major complication of allogeneic hematopoietic stem cell transplant (allo-HSCT) is the potential transfer of autoimmune conditions from the donor to the host. We describe a case of a Non- Hodgkin’s Lymphoma patient who received an allo-HSCT from her HLA-matched brother who had psoriasis. Her transplant course was complicated by graft-versus-host disease, managed with prednisone and tacrolimus. Nearly two years post-transplant, she developed psoriatic arthritis. We highlight a rare case of late-onset or masked adoptive autoimmunity presenting as psoriatic arthritis post-allo-HSCT. This case demonstrates a need to monitor delayed autoimmune presentations in transplant patients who develop graft-versus-host disease.