The Potential Role of Cell-Death Mechanisms in the Pathogenesis of Familial Mediterranean Fever Attacks: Granzyme A and Beyond
Our study on death pathways during an FMF attack, suggests an upregulation in both pyroptosis through the granzyme-gasdermin pathway and apoptosis with the increased FasL and perforin levels, which was different from PFAPA patients. These findings might shed light on the reason for the nature of self-limited attacks, but further studies are needed to prove this hypothesis.
Authors
- Oğuz Bölük (ORCID: https://orcid.org/0000-0003-3283-1370)
- Medine Ayşin Taşar (ORCID: https://orcid.org/0000-0003-4367-725X)
- Yağmur Bayındır (ORCID: https://orcid.org/0000-0001-5274-3285)
- Erdal Sağ (ORCID: https://orcid.org/0000-0002-6542-2656)
- Seza Özen (ORCID: https://orcid.org/0000-0003-2883-7868)
- Ece Yaglikara
- Yelda Bilginer
Institutions
- Ministry of Health (TR)
- Hacettepe University (TR)
Publication Details
- Journal
- Diagnostics
- Published
- 2024-09-13
- DOI
- https://doi.org/10.3390/diagnostics14182031
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23