Antibacterial effect and mechanisms of action of forsythoside B, alone and in combination with antibiotics, against Acinetobacter baumannii and Pseudomonas aeruginosa
FB expands the antibacterial spectrum and enhances the effectiveness of existing antibiotics against resistant bacterial strains, making it a promising adjuvant for treating gram-negative bacterial infections. This study highlights the potential of FB in combating antibiotic resistance and suggests further research into its mechanisms and drug development applications. It provides a framework for studying the interaction between natural products and microorganisms, revealing new biological mechanisms.
Authors
- Xiuding Yang
- Chengyuan Liang (ORCID: https://orcid.org/0000-0001-7360-8998)
- Yanzi Wang (ORCID: https://orcid.org/0000-0001-8533-0233)
- Qianqian Zhao (ORCID: https://orcid.org/0000-0002-4377-4933)
- Lei Tian (ORCID: https://orcid.org/0000-0002-9051-9468)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-4780-8889)
- Han Li (ORCID: https://orcid.org/0000-0001-8579-1515)
- Qi Lu (ORCID: https://orcid.org/0000-0001-7603-4360)
- Zhenfeng Shi (ORCID: https://orcid.org/0009-0001-0260-3097)
- Changhua Ke
- Sichang Hao
Institutions
- Xi'an University of Science and Technology (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.phymed.2024.156038
- Citations
- 6
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Shaanxi Administration of Traditional Chinese Medicine
- National Natural Science Foundation of China
- Natural Science Foundation of Shaanxi Province
- Xi'an Municipal Bureau of Science and Technology
- Shaanxi Provincial Science and Technology Department
- Scientific Research Plan Projects of Shaanxi Education Department