The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients
The results of recent studies show that tumor biology, coagulation activation, and inflammatory reactions profoundly contribute to the thrombosis pathogenesis in cancer as well as tumor progression, metastasis, and developing chemoresistance. Cancer is an independent predictor of thrombosis. During carcinogenesis, tumor cells express proinflammatory cytokines, proangiogenic and procoagulant factors, and also stimulate other cells to express various components promoting emerging thromboinflammation. The discovery of neutrophil extracellular traps (NETs) provides an opportunity to take a new look at biology and a role neutrophils may play in thromboinflammation and tumorigenesis. The close interplay between tumor cells, tumor-associated neutrophils and NETs as well as other players in the tumor microenvironment underlies activation of thromboinflammation in cancer patients not only resulting in thrombus formation, but also promoting tumor growth and dissemination.
Authors
- N. R. Gashimova (ORCID: https://orcid.org/0000-0003-0764-4477)
- В. Н. Серов (ORCID: https://orcid.org/0000-0003-2976-7128)
- К. N. Grigoreva (ORCID: https://orcid.org/0000-0002-7756-8935)
- Konstantin Zakashansky (ORCID: https://orcid.org/0000-0003-2038-0023)
- A. Е. Voynovskiy (ORCID: https://orcid.org/0000-0003-4761-5793)
- N. А. Makatsariya (ORCID: https://orcid.org/0000-0002-2541-3843)
- M. V. Tretyakova (ORCID: https://orcid.org/0000-0002-3628-0804)
- Е. V. Slukhanchuk (ORCID: https://orcid.org/0000-0001-7441-2778)
- J. Kh. Khizroeva (ORCID: https://orcid.org/0000-0002-0725-9686)
- Polina Salnikova (ORCID: https://orcid.org/0000-0003-2011-1237)
- J. Yu. Ungiadze (ORCID: https://orcid.org/0000-0002-3337-4995)
- L. А. Ashrafyan (ORCID: https://orcid.org/0000-0001-6396-4948)
- В. О. Бицадзе (ORCID: https://orcid.org/0000-0001-8404-1042)
- Jean‐Christophe Gris (ORCID: https://orcid.org/0000-0002-9899-9910)
- Ismaı̈l Elalamy (ORCID: https://orcid.org/0000-0002-9576-1368)
- А. Г. Солопова (ORCID: https://orcid.org/0000-0002-7456-2386)
- А. D. Makatsariya (ORCID: https://orcid.org/0000-0001-7415-4633)
- А. V. Lazarchuk (ORCID: https://orcid.org/0000-0003-2136-1641)
Institutions
- Batumi Shota Rustaveli State University (GE)
- Sechenov University (RU)
- Université de Montpellier (FR)
- Sorbonne Université (FR)
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation (RU)
- City Clinical Hospital (RU)
- Hôpital Tenon (FR)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Obstetrics Gynecology and Reproduction
- Published
- 2024-09-12
- DOI
- https://doi.org/10.17749/2313-7347/ob.gyn.rep.2024.542
- Citations
- 4
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.96