Symptomatic aseptic sinusitis induced by immune checkpoint inhibitors for metastatic melanoma treatment
Immune-mediated sinusitis is poorly described and may easily go undiagnosed. We conducted a retrospective, multicenter, national study focusing on symptomatic immune-mediated sinusitis in patients receiving immune checkpoint inhibitors (ICIs) for melanoma treatment. Twelve patients were included (50% women, median age 58 years). Overall, the paraclinical assessment, the inefficacy of antibiotic/antihistaminic treatment, the improvement of symptoms on immunosuppressants and/or after ICI discontinuation, and the presence of multiple concomitant immune-related adverse-events, suggested a noninfectious etiology. Recognizing this toxicity is imperative for limitation of diagnostic wandering and appropriate treatment. However, additional epidemiological studies are needed to assess its prevalence as a potential immune-related adverse-event, and its prognostic value in patients treated with ICIs.
Authors
- S. Tzoumpa (ORCID: https://orcid.org/0000-0002-8129-5933)
- Alexandre Memmi
- Charlée Nardin
- F. Granel‐Brocard
- Elisa Funck‐Brentano (ORCID: https://orcid.org/0000-0002-1092-0789)
- G. Jeudy (ORCID: https://orcid.org/0009-0003-7065-9097)
- E. Maubec (ORCID: https://orcid.org/0000-0003-1658-6686)
- Caroline Dutriaux (ORCID: https://orcid.org/0000-0002-9836-5168)
- M. Saint‐Jean (ORCID: https://orcid.org/0000-0003-4454-0749)
- Yannick Le Corre (ORCID: https://orcid.org/0000-0003-3089-3068)
- Victor Tafani
- B. Villette
- Gaelle Quereux (ORCID: https://orcid.org/0000-0002-1739-1701)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Cancérologie de l'Ouest (FR)
- Hôpital Saint-André (FR)
- Hôpital Ambroise-Paré (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- Groupe Hospitalier Intercommunal Le Raincy Montfermeil (FR)
- Immunologie et Nouveaux Concepts en Immunothérapie
- Université d'Angers (FR)
Publication Details
- Journal
- Immunotherapy
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1080/1750743x.2024.2399498
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57