Sclerosing Epithelioid Fibrosarcoma Harboring the EWSR1–CREB3L1 Gene Fusion: The Importance of Molecular Classification in Pediatric Sarcomas
SEF is typically identified via genetic testing and recognition of the EWSR1 - CREB3L1 gene fusion as well as MUC4 expression via immunohistochemistry. DNA methylation profiling, which has traditionally been used in brain tumors, can also efficiently identify this tumor, and we recommend expanding the use of this technology for difficult to classify pediatric sarcomas.
Authors
- Rachel Offenbacher (ORCID: https://orcid.org/0000-0002-5211-6457)
- David M. Loeb (ORCID: https://orcid.org/0000-0002-7319-5000)
- Alissa C. Baker (ORCID: https://orcid.org/0000-0001-9388-5650)
- Lara Fabish
- Carly C. Barron (ORCID: https://orcid.org/0000-0002-9042-0150)
- Alice Lee (ORCID: https://orcid.org/0000-0003-0188-0612)
- Matija Snuderl (ORCID: https://orcid.org/0000-0003-0752-0917)
- Jana Fox (ORCID: https://orcid.org/0000-0002-8526-8588)
- Steven S. Chin (ORCID: https://orcid.org/0000-0002-7096-7044)
- Sara Kaswan
Institutions
- Albert Einstein College of Medicine (US)
- NYU Langone Health (US)
- Children's Hospital at Montefiore (US)
- Radiation Oncology Associates (US)
Publication Details
- Journal
- Journal of Pediatric Hematology/Oncology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1097/mph.0000000000002952
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00