Supplementation with Lactobacillus helveticus NS8 alleviated behavioral, neural, endocrine, and microbiota abnormalities in an endogenous rat model of depression
The depressive phenotype of Wistar-Kyoto rats is not only attributed to their genetic context but also closely related to their gut microbiota. Abnormal gut microbiota and a dysfunctional microbiota-gut-brain axis play important roles in endogenous depression, just as they do in exogenous depression. Supplementing with probiotics such as <i>L. helveticus</i> NS8 is likely a promising approach to improve endogenous depression and treatment-resistant depression.
Authors
- Katsunori Iijima (ORCID: https://orcid.org/0000-0003-3482-9979)
- Jia Luo (ORCID: https://orcid.org/0000-0001-7725-199X)
- Tao Wang (ORCID: https://orcid.org/0000-0001-9732-1617)
- Yosuke Shimodaira (ORCID: https://orcid.org/0000-0003-0314-9196)
- Feng Jin (ORCID: https://orcid.org/0000-0002-0325-5362)
- Xiaoli Wu (ORCID: https://orcid.org/0000-0003-2976-1797)
- Shan Liang (ORCID: https://orcid.org/0000-0002-1618-1374)
- Xu Hu (ORCID: https://orcid.org/0000-0002-8556-6059)
- Husile Alatan
Institutions
- Akita University (JP)
- Akita Research Institute for Food and Brewing (JP)
- Institute of Psychology, Chinese Academy of Sciences (CN)
- Chengdu Normal University (CN)
- Sichuan Normal University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.3389/fimmu.2024.1407620
- Citations
- 18
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 5.88