Highly Enantioselective Synthesis of Polycyclic Dihydroisoquinolinones via NHC-Catalyzed [4 + 2] Annulations
The NHC-catalyzed enantioselective [4 + 2] annulation of 9<i>H</i>-fluorene-1-carbaldenydes with cyclic imines was successfully developed. A series of optically enriched polycyclic dihydroisoquinolinones were synthesized in moderate to excellent yields with good to excellent enantioselectivities. In addition, this efficient method could also be amenable to the synthesis of spirocyclic compounds by using isatin-derived ketimines as the electrophiles.
Authors
- Yuxuan Feng
- Xiaoyong Duan (ORCID: https://orcid.org/0000-0002-2666-015X)
- Xiaojie Ren (ORCID: https://orcid.org/0000-0003-2532-7600)
- Jiahan Li (ORCID: https://orcid.org/0000-0002-5118-0908)
- Jing Qi (ORCID: https://orcid.org/0000-0003-1612-0229)
- Yanting Li (ORCID: https://orcid.org/0000-0003-2973-3016)
Institutions
- Hebei University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1021/acs.joc.4c01529
- Citations
- 5
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- Natural Science Foundation of Hebei Province
- Hebei University