Protein and transcriptional biomarker profiling may inform treatment strategies in lower respiratory tract infections by indicating bacterial–viral differentiation
Accurate differentiation between bacterial and viral lower respiratory tract infections (LRTIs) is vital for effective patient care and resource allocation. This study investigated specific protein signatures and gene expression patterns in plasma and blood samples from LRTI patients that distinguished bacterial and viral infections. The identified signatures can inform the design of point-of-care tests that can aid healthcare providers in making informed decisions about antibiotic prescriptions in order to reduce unnecessary use, thereby contributing to reduced side effects and antibiotic resistance. Furthermore, the potential for faster and more accurate diagnoses for improved patient management in acute LRTIs is compelling.
Authors
- Dagfinn Lunde Markussen (ORCID: https://orcid.org/0000-0003-3504-8859)
- Dhanasekaran Sivakumaran (ORCID: https://orcid.org/0000-0003-1688-8182)
- Siri Tandberg Knoop (ORCID: https://orcid.org/0000-0002-9382-8186)
- Sondre Serigstad (ORCID: https://orcid.org/0000-0002-2582-8328)
- Harleen M. S. Grewal
- Christina Skår Saghaug (ORCID: https://orcid.org/0000-0003-0836-7889)
- Elling Ulvestad (ORCID: https://orcid.org/0000-0001-5901-8422)
- Aashish Srivastava (ORCID: https://orcid.org/0000-0003-0532-3979)
- Synne Jenum (ORCID: https://orcid.org/0000-0001-8187-775X)
Institutions
- Oslo University Hospital (NO)
- Haukeland University Hospital (NO)
- University of Bergen (NO)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1128/spectrum.02831-23
- Citations
- 2
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- GlaxoSmithKline
- Trond Mohn stiftelse
- Norges Forskningsråd
- Haukeland Universitetssjukehus