ASSESSMENT OF ANTIOXIDANT, HYPOGLYCEMIC AND HYPOLYPIDEMIC ACTIVITIES OF THE HERBAL EXTRACT OF HILL-GROWING SALTWORT (SALSOLA COLLINA)

Introduction. The development of safe and effective natural antioxidant drugs is an important task in the prevention and treatment of cardiovascular diseases, which are a serious public health problem. Work Objective is a study of the antioxidant, hypoglycemic and hypolipidemic activities of the herbal extract of hill-growing saltwort (Salsola collina) in comparison with the effect of a standard antioxidant agent. Material and methods. The object of the study was a "Hepatosol" biologically active food supplement based on a dry concentrated aqueous extract of the Salsola collina herb in capsules. The patients under observation were matched groups of obese women and men of comparable age with risk factors for cardiovascular diseases. Dur-ing the study, tolerability and possible adverse events were recorded and vital signs were monitored. The results of a biochemical blood test, lipid pro-file, oxidative stress and body composition analysis of patients were also evaluated and interpreted. Results. It has been found out that the parameters of the lipid profile and antioxidant status in patients with obesity and a risk of cardiovascular com-plications taking the herbal extract of hill-growing saltwort for 3 months returned to normal. A hypoglycemic positive effect of the herbal extract of hill-growing saltwort on reducing the body weight of patients has been recorded. The safety and good tolerability of the study drug have been confirmed. Conclusions. The results of studies show that a biologically active food supplement "Hepatosol" based on the extract of the Salsola collina herb has antioxidant, hypoglycemic and hypolipidemic activities. Due to these properties, the drugs based on a dry concentrated aqueous extract of the Salsola collina herb are favorable for diet therapy of patients with diabetes mellitus, for weight loss and use in the prevention and complex therapy of cardio-vascular diseases.