No replicating evidence for anti‐amyloid‐β autoantibodies in cerebral amyloid angiopathy‐related inflammation
We were unable to reproduce the reported elevation of anti-Aβ autoantibody concentration in CSF of CAA-RI patients. Our findings instead support nonspecific detection of IgG levels in CSF by the assay. Reviewed CAA-RI case reports suggested a widespread cerebral inflammatory reaction. In conclusion, our findings do not support anti-Aβ autoantibodies as a diagnostic biomarker for CAA-RI.
Authors
- Andreas Charidimou (ORCID: https://orcid.org/0000-0001-5891-337X)
- Delphine Boche (ORCID: https://orcid.org/0000-0002-5884-130X)
- Marcel M. Verbeek (ORCID: https://orcid.org/0000-0003-4635-7876)
- Floris H.B.M. Schreuder (ORCID: https://orcid.org/0000-0002-7815-0207)
- Ellis S. van Etten (ORCID: https://orcid.org/0000-0002-8301-6846)
- E. van den Berg (ORCID: https://orcid.org/0000-0001-9004-934X)
- Catharina J.M. Klijn (ORCID: https://orcid.org/0000-0002-8495-4578)
- Steven Mark Greenberg (ORCID: https://orcid.org/0000-0003-1792-8887)
- Lieke Jäkel (ORCID: https://orcid.org/0000-0002-9378-3256)
- H. Bea Kuiperij (ORCID: https://orcid.org/0000-0002-0635-7428)
- Rian Roelofs
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Massachusetts General Hospital (US)
- University of Southampton (GB)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1002/acn3.52169
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Stryker
- Health~Holland
- Medtronic
- ZonMw
- Leids Universitair Medisch Centrum
- Radboud Universitair Medisch Centrum
- Zorginstituut Nederland
- Alzheimer Nederland
- National Institutes of Health