A new scoring system to predict survival in elderly advanced stage Hodgkin lymphoma patients
Predictive prognostic scoring (PS) systems are not primarily applicable to elderly patients with classical Hodgkin lymphoma (cHL). The objective of this study was to develop a PS system for these patients. The derivation cohort (DC) was utilized for model development, consisting of 97 variables. The resulting algorithm was named as Hodgkin's Lymphoma Early Death in the Elderly within 12 months (HEDEL12). Internal and external validation cohorts (IVC and EVC) were employed for validation. A total of 286 patients were evaluated retrospectively. In DC 38 of 178 patients died within the first 12 months and overall survival (OS) at 12-month was 78.6%. Independent predictors of HEDEL12 were female sex, low albumin levels (<3.5 g/dL), and ECOG scores 2-4. According to HEDEL12 scores 0-1, OS at 12- months were 89.8% and 91.0% for IVC and EVC, respectively. The HEDEL12 scoring is useful in predicting the survival of advanced-stage cHL patients.
Authors
- Semra Paydaş (ORCID: https://orcid.org/0000-0003-4642-3693)
- Fevzi Altuntaş
- Tahir Darçın (ORCID: https://orcid.org/0000-0001-5073-1790)
- Hakkı Onur Kırkızlar (ORCID: https://orcid.org/0000-0001-7523-8599)
- Fatma Keklik Karadağ (ORCID: https://orcid.org/0000-0001-6078-5944)
- Işık Atagündüz (ORCID: https://orcid.org/0000-0002-7876-6896)
- Tayfur Toptaş (ORCID: https://orcid.org/0000-0002-2690-8581)
- Ünal Ataş (ORCID: https://orcid.org/0000-0001-5897-6514)
- Salih Sertaç Durusoy (ORCID: https://orcid.org/0000-0002-3577-6330)
- Vildan Gürsoy (ORCID: https://orcid.org/0000-0002-3645-9345)
- Olga Meltem Akay (ORCID: https://orcid.org/0000-0002-6759-1939)
- Elif Birtaş Ateşoğlu (ORCID: https://orcid.org/0000-0002-2596-4493)
- Anıl Tombak (ORCID: https://orcid.org/0000-0002-7195-1845)
- Burhan Ferhanoğlu (ORCID: https://orcid.org/0000-0002-4257-549X)
- Sinem Civriz Bozdağ (ORCID: https://orcid.org/0000-0001-8359-7794)
- Fahir Özkalemkaş (ORCID: https://orcid.org/0000-0001-9710-134X)
- Volkan Karakuş (ORCID: https://orcid.org/0000-0001-9178-2850)
- Güner Hayri Özsan (ORCID: https://orcid.org/0000-0002-0930-6300)
- Nurhilal Büyükkurt (ORCID: https://orcid.org/0000-0002-0895-4787)
- Elçin Erdoğan Yücel (ORCID: https://orcid.org/0000-0002-8551-868X)
- Mehmet Sinan Dal (ORCID: https://orcid.org/0000-0002-5994-2735)
- Atakan Teki̇nalp (ORCID: https://orcid.org/0000-0001-7937-4045)
- Emrah Kılıçaslan (ORCID: https://orcid.org/0000-0002-0944-4068)
- Özgür Mehtap (ORCID: https://orcid.org/0000-0002-5603-1178)
- Mehmet Ali Uçar (ORCID: https://orcid.org/0000-0002-6041-7364)
- Muhıt Özcan (ORCID: https://orcid.org/0000-0002-1326-1918)
- Ozan Salim (ORCID: https://orcid.org/0000-0001-6687-0189)
- Güray Saydam (ORCID: https://orcid.org/0000-0001-8646-1673)
- Mehmet Yılmaz (ORCID: https://orcid.org/0000-0002-1218-8165)
- Nilgün Sayınalp (ORCID: https://orcid.org/0000-0002-4782-896X)
- Erkin Çinar
- Fatma Gecgel Arikan
- Funda Pepedi
Institutions
- Yeditepe University (TR)
- Trakya University (TR)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Koç University (TR)
- Ankara University (TR)
- Başkent University (TR)
- Dokuz Eylül University (TR)
- Akdeniz University (TR)
- Ege University (TR)
- Gülhane Askerî Tıp Akademisi (TR)
- Adana Hospital (TR)
- Necmettin Erbakan University (TR)
- Ankara Onkoloji Eğitim ve Araştırma Hastanesi (TR)
- Akdeniz University Hospital (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Başkent University Hospital (TR)
- Sanko University (TR)
- Mersin Üniversitesi (TR)
- Kocaeli Üniversitesi (TR)
- Cukurova University (TR)
- Hacettepe University (TR)
- Marmara University (TR)
Publication Details
- Journal
- Leukemia & lymphoma/Leukemia and lymphoma
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1080/10428194.2024.2395458
- Citations
- 5
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.12