Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
These observations underscore the critical role of timing and disease context in order to optimize the therapeutic efficacy of immune modulators combined with androgen ablation, for which the presurgical neoadjuvant setting may be ideal. Our findings warrant future prospective validation, which is currently underway.
Authors
- Matthew C. Dallos (ORCID: https://orcid.org/0000-0002-5412-3490)
- Dana E. Rathkopf (ORCID: https://orcid.org/0000-0002-4503-7582)
- Aditya Pratapa (ORCID: https://orcid.org/0000-0002-3323-6250)
- Christopher Gaffney (ORCID: https://orcid.org/0000-0002-7785-6611)
- Patrick McCann (ORCID: https://orcid.org/0000-0002-1836-4617)
- Charles G. Drake (ORCID: https://orcid.org/0000-0001-9610-3677)
- Aleksandar Obradović (ORCID: https://orcid.org/0000-0002-8009-0186)
- Renu K. Virk (ORCID: https://orcid.org/0000-0002-2984-4202)
- David H. Aggen (ORCID: https://orcid.org/0000-0003-3963-5751)
- Nivedita Chowdhury (ORCID: https://orcid.org/0000-0001-7327-3067)
- Howard I. Scher (ORCID: https://orcid.org/0000-0002-6791-9324)
- Angelo M. De Marzo (ORCID: https://orcid.org/0000-0003-4847-5307)
- Karen A. Autio (ORCID: https://orcid.org/0000-0003-0720-0390)
- Emmanuel S. Antonarakis (ORCID: https://orcid.org/0000-0003-0031-9655)
Institutions
- University of Minnesota (US)
- Memorial Sloan Kettering Cancer Center (US)
- Johns Hopkins University (US)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- University of Minnesota System (US)
- University of Minnesota Medical Center (US)
- Universidad San Carlos (PY)
- Akoya Biosciences (United States) (US)
- Herbert Irving Comprehensive Cancer Center
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0060
- Citations
- 15
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- U.S. Department of Defense
- Prostate Cancer Foundation
- National Cancer Institute