Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer
In conclusion, DNA hypomethylation by 5-azacitidine exhibits a close association with H3K27me3 and PRC activity in BRAFV600E colorectal cancer, and simultaneous blockade of DNA methyltransferase and EZH2 holds promise as a potential therapeutic strategy for patients with BRAFV600E-mutated colorectal cancer.
Authors
- Abhinav K. Jain (ORCID: https://orcid.org/0000-0003-3268-514X)
- Stefania Napolitano (ORCID: https://orcid.org/0000-0003-3504-8349)
- Scott Kopetz (ORCID: https://orcid.org/0000-0001-9647-3416)
- Ajay Kumar Saw (ORCID: https://orcid.org/0000-0002-9872-9582)
- Michael Peoples (ORCID: https://orcid.org/0000-0001-5233-2603)
- Van Karlyle Morris (ORCID: https://orcid.org/0000-0002-4911-2252)
- Christopher A. Bristow (ORCID: https://orcid.org/0009-0009-9266-6849)
- Anand K. Singh (ORCID: https://orcid.org/0000-0002-6855-3352)
- Hey Min Lee (ORCID: https://orcid.org/0000-0001-7792-4226)
- Christopher Terranova (ORCID: https://orcid.org/0000-0002-3674-7013)
- Jonathan Schulz (ORCID: https://orcid.org/0000-0003-2679-9829)
- Alexey V. Sorokin (ORCID: https://orcid.org/0000-0002-9682-8085)
- Preeti Kanikarla Marie (ORCID: https://orcid.org/0000-0002-4913-8575)
- Kunal Rai (ORCID: https://orcid.org/0000-0003-2321-6894)
- Oluwadara Coker (ORCID: https://orcid.org/0000-0003-0504-2747)
- Sanjana Srinivasan
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1166
- Citations
- 12
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- U.S. Department of Defense
- Cancer Prevention and Research Institute of Texas
- Northwestern University
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- Robert H. Lurie Comprehensive Cancer Center
- National Cancer Institute