Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway
Administration of UC-MSCs and UC-MSCs-derived EVs on day 6 of CTX/BUS injection could effectively improve the ovarian function of POF mice. UC-MSCs-derived EVs carrying CLU promoted proliferation and inhibited apoptosis of ovarian granulosa cells through activating the PI3K/AKT pathway. This study identifies a previously unrecognized molecular mechanism of UC-MSCs-mediated protective effects on POF, which pave the way for the use of cell-free therapeutic approach for POF.
Authors
- Taoran Deng (ORCID: https://orcid.org/0000-0002-6118-6529)
- Chunchun Ao (ORCID: https://orcid.org/0009-0003-9386-1634)
- Dongcheng Wu (ORCID: https://orcid.org/0000-0002-2989-7291)
- M. Li (ORCID: https://orcid.org/0009-0002-7945-3960)
- Changyong Li (ORCID: https://orcid.org/0000-0003-4001-037X)
- Yijia Jiang (ORCID: https://orcid.org/0009-0003-5368-4020)
- Shuo Zheng
- Ruibo Lang (ORCID: https://orcid.org/0009-0006-7618-7862)
- Chengshu Tu
- Yu Ouyang (ORCID: https://orcid.org/0000-0002-2418-281X)
- Jing He (ORCID: https://orcid.org/0000-0003-3904-8928)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-6527-3427)
- Yifan Yang (ORCID: https://orcid.org/0009-0003-0588-1812)
Institutions
- Wuhan University (CN)
- Wuhan Science and Technology Bureau (CN)
- Hubei University of Science and Technology (CN)
- Nanfang Hospital (CN)
- Guangzhou Automobile Group (China) (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1186/s13287-024-03926-7
- Citations
- 23
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 6.50
Funders
- Science and Technology Bureau, Guiyang Municipal Government
- Wuhan Municipal Science and Technology Bureau