Assessment of chromatography separation parameters in the quality control of copper-64-labeled neurotensin-like peptides
Abstract In recent years, research on the Cu-64 effects on malignant tumours has increased, leading to the development of radiopharmaceuticals with higher selectivity, aiming to target tumour cells while preserving healthy body cells. This work aims to assess the quality of two DOTA-derivatized neuropeptides, NMN and NT (8-13) radiolabelled with Cu-64. An improved analytical radio-HPLC method was developed to evaluate the radiochemical purity and stability. The radiochemical purity is > 99.95% for both 64 Cu-DOTA-NMN and 64 Cu-DOTA-NT (8-13), the radiolabelled molecules being stable for 72 h after synthesis.
Authors
- Radu M. Serban
- Livia Chilug (ORCID: https://orcid.org/0000-0001-6553-8213)
- Simona Băruță (ORCID: https://orcid.org/0000-0003-4485-6831)
- Diana Cocioabă (ORCID: https://orcid.org/0000-0002-0445-0581)
- Dana Niculae (ORCID: https://orcid.org/0000-0002-4769-843X)
- Maria-Roxana Tudoroiu-Cornoiu
- Alina Catrinel Ion
Institutions
- University of Bucharest (RO)
- Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering (RO)
- Extreme Light Infrastructure - Nuclear Physics (RO)
- Universitatea Națională de Știință și Tehnologie Politehnica București (RO)
Publication Details
- Journal
- Journal of Radioanalytical and Nuclear Chemistry
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1007/s10967-024-09694-1
- Citations
- 1
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Ministerul Cercetării, Inovării şi Digitalizării