How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate

The evaluation of estimated GFR (eGFR) is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The interaction between histopathological diagnosis and ultrasound parameters in eGFR determination has not been fully investigated yet. The study examined the results of native kidney biopsies performed in 48 Italian centers between 2012 and 2020. The primary goal was if and how the histopathological diagnosis influences the relationship between ultrasound parameters and eGFR. After exclusion of children, patients with acute kidney injury and patients without measure of kidney length or parenchymal thickness, 2795 patients have been selected for analysis. The median values were 52 years for patient age, 11 cm for bipolar kidney diameter, 16 mm for parenchymal thickness, 2.5 g/day for proteinuria and 70 ml/min/1.73 m<sup>2</sup> for eGFR. The bipolar kidney diameter and the parenchymal thickness were directly related with eGFR values (R square 0.064). Diabetes and proteinuria were associated with a consistent reduction of eGFR, improving the adjusted R square up to 0.100. Addition of histopathological diagnosis in the model increased the adjusted R square to 0.216. There is a significant interaction between histopathological diagnosis and longitudinal kidney diameter (P 0.006). Renal bipolar length and parenchymal thickness are directly related with eGFR. The magnitude of proteinuria and histopathological kidney diagnosis are associated with eGFR. The relationship between kidney length and the level of eGFR depends on the nature of the kidney disease.

Authors

Institutions

Publication Details

Journal
Internal and Emergency Medicine
Published
2024-09-13
DOI
https://doi.org/10.1007/s11739-024-03711-7
Citations
1
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
0.34
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate

Filippo Aucella, Brigida Di Renzo, Gioacchino Li Cavoli, Gianmarco Sabiu et al.
1 citations
Internal and Emergency Medicine
Chronic Kidney Disease and Diabetes
0.34
article

How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate

Filippo Aucella, Brigida Di Renzo, Gioacchino Li Cavoli, Gianmarco Sabiu, Marco Quaglia, Domenico Giannese, Luisa Benozzi, Yuri Battaglia, Mario Bonomini, Maria Giovanna Vario, Guido Gembillo, Valentina Corbani, Maurizio Garozzo, Maurizio Borzumati, Michele Rossini, M Conte, Massimo Manes, Simeone Andrulli, Barbara Infante, Fulvia Zanchelli, Elisabetta Moggia, Rosario Cianci, Marco De Fabritiis, Gisella Vischini, Rosa Maria Pollastro, G Pasquariello, Flavia Manenti, Roberta Lazzarin, Pierluigi D’Angiò, Raffaela Sciri, Antonietta Gigante, Giovanni Valsecchi, Antonio Granata, Giovanni Andrulli, Arcangelo Di Maggio, Franca Luchetta, Giuseppe Seminara, Marco Leoni, Loreto Gesualdo, Enrica Gintoli
article en
1 citations

Abstract

The evaluation of estimated GFR (eGFR) is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The interaction between histopathological diagnosis and ultrasound parameters in eGFR determination has not been fully investigated yet. The study examined the results of native kidney biopsies performed in 48 Italian centers between 2012 and 2020. The primary goal was if and how the histopathological diagnosis influences the relationship between ultrasound parameters and eGFR. After exclusion of children, patients with acute kidney injury and patients without measure of kidney length or parenchymal thickness, 2795 patients have been selected for analysis. The median values were 52 years for patient age, 11 cm for bipolar kidney diameter, 16 mm for parenchymal thickness, 2.5 g/day for proteinuria and 70 ml/min/1.73 m<sup>2</sup> for eGFR. The bipolar kidney diameter and the parenchymal thickness were directly related with eGFR values (R square 0.064). Diabetes and proteinuria were associated with a consistent reduction of eGFR, improving the adjusted R square up to 0.100. Addition of histopathological diagnosis in the model increased the adjusted R square to 0.216. There is a significant interaction between histopathological diagnosis and longitudinal kidney diameter (P 0.006). Renal bipolar length and parenchymal thickness are directly related with eGFR. The magnitude of proteinuria and histopathological kidney diagnosis are associated with eGFR. The relationship between kidney length and the level of eGFR depends on the nature of the kidney disease.

Internal and Emergency MedicineVol. 19(8)
University of Foggia (IT), University of Messina (IT), Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT), University of Campania "Luigi Vanvitelli" (IT), Casa Sollievo della Sofferenza (IT), CTO Hospital (IT), Ospedale Santa Chiara (IT), Ospedale "Santa Maria delle Croci" di Ravenna (IT), San Salvatore Hospital (IT), Ospedale Vincenzo Cervello (IT), Santa Maria Nuova Hospital (IT), Ospedale A. Perrino (IT), Nuovo Ospedale San Giovanni di Dio (IT), Ospedale San Giacomo Apostolo (IT), Ospedale Santa Maria (IT), CTO Andrea Alesini (IT), Azienda USL di Bologna (IT), Azienda Ospedaliero Universitaria Maggiore della Carita (IT), Santissima Trinità (IT), Ospedale G.B. Morgagni - L.Pierantoni (IT), Italian Association for Cancer Research (IT), Ospedale di Belcolle (IT), Ospedale Cannizzaro (IT), Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT), Ospedale Regina Apostolorum (IT), Azienda Ospedaliera Ospedale Maggiore (IT), Hospital de Santa Marta (PT), Ospedale Sant'Anna (IT), Ospedale SS. Annunziata (IT), ASST Fatebenefratelli Sacco (IT), Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT), Azienda Sanitaria Locale Roma 3 (IT), Azienda Ospedaliera Universitaria Pisana (IT), University of Bari Aldo Moro (IT), Misericordia University (US), Bocconi University (IT), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 35%
Chronic Kidney Disease and Diabetes
0.34
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.