Alternating magnetic fields (AMF) and linezolid reduce Staphylococcus aureus biofilm in a large animal implant model
This study demonstrates that combining AMF with antibiotics significantly reduces biofilm-associated infections on metal implants in a large animal model. Numerical simulations confirmed targeted heating, and in vivo results showed substantial bacterial load reduction and reduced inflammatory response. These findings support the potential of AMF as a non-invasive treatment for prosthetic joint infections.
Authors
- Marguerite L. Monogue (ORCID: https://orcid.org/0000-0001-8251-458X)
- Jacob Adams (ORCID: https://orcid.org/0000-0001-8855-9201)
- Dustin L. Williams (ORCID: https://orcid.org/0000-0001-5275-1365)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Tyler B. Smith (ORCID: https://orcid.org/0000-0002-5256-6087)
- Bibin Prasad (ORCID: https://orcid.org/0000-0002-8607-0098)
- Brooke Kawaguchi (ORCID: https://orcid.org/0000-0001-8536-3078)
- David E. Greenberg (ORCID: https://orcid.org/0000-0002-5101-3106)
- Christine Pybus (ORCID: https://orcid.org/0000-0002-4895-6525)
- Rajiv Chopra (ORCID: https://orcid.org/0000-0003-3605-6076)
- Connor Hunt (ORCID: https://orcid.org/0000-0001-8439-3814)
- John M. Shelton (ORCID: https://orcid.org/0000-0002-2949-1638)
- Bret M. Evers (ORCID: https://orcid.org/0000-0001-5686-0315)
- John Tepper
- Varun Sadaphal (ORCID: https://orcid.org/0000-0002-2244-4011)
- Walker Kay
- Isuru A Somawardana
- Rousselle Serge
- Josue I Ramirez
- O. Jones
Institutions
- Texas Medical Center (US)
- University of Utah (US)
- Southwestern Medical Center (US)
- CTL Amedica (United States) (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1016/j.jinf.2024.106271
- Citations
- 6
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases