Spatially fractionated GRID radiation potentiates immune-mediated tumor control
This study demonstrates the pivotal role of the radiation-induced anti-tumor immunity. Prolonged fractionated treatment schedules may counteract early immune recruitment, which may be protected by SFRT-facilitated immune reservoirs. Different biological responses and treatment outcomes are observed based on pre-treatment TIME composition and model parameters. A rigorous analysis and model calibration for different tumor types and immune infiltration states is required before any conclusions can be drawn for clinical translation.
Authors
- Shari Pilon‐Thomas (ORCID: https://orcid.org/0000-0001-7785-3034)
- Heiko Enderling (ORCID: https://orcid.org/0000-0002-9696-6410)
- Gage Redler (ORCID: https://orcid.org/0000-0001-8755-9218)
- Kosj Yamoah (ORCID: https://orcid.org/0000-0001-9055-3538)
- Jimmy J. Caudell (ORCID: https://orcid.org/0000-0001-6417-2483)
- Eduardo G. Moros (ORCID: https://orcid.org/0000-0003-1964-2460)
- José Peñagarícano (ORCID: https://orcid.org/0000-0002-2385-1962)
- Rebecca A Bekker (ORCID: https://orcid.org/0000-0002-3002-2724)
- Nina Obertopp (ORCID: https://orcid.org/0009-0006-5100-1590)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of South Florida (US)
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.1186/s13014-024-02514-6
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- University of South Florida
- Moffitt Cancer Center
- National Institutes of Health